SNP'ing for longevity
نویسندگان
چکیده
منابع مشابه
SNPing away at innate immunity.
(CF) is a genetic disorder caused by mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) (1). A hallmark of the disease is a defect in chloride con-ductance, particularly in serous gland cells and respiratory epithelial cells. Depletion of the periciliary liquid layer, partly due to a defect in ciliary transport, has pleiotropic consequences with respect to local host def...
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We develop regression methodology to identify subsets of single nucleotide polymorphisms (SNPs) within candidate genes related to quantitative traits and apply our methods to the simulated Genetic Analysis Workshop (GAW) 12 data set. In the data set we find 694 SNP loci with minimum allele frequencies of at least 0.01. We assume an additive casual model between these SNPs and all five quantitat...
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was well tolerated in phase 1 and 2 studies, and therefore has already passed its first important test. Nevertheless, inhibition of JAK2 raises concerns, since JAK2 is required for signaling by the receptors for erythropoietin, thrombopoietin, and in part, G-CSF. In this respect, it is encouraging that cells carrying JAK2-V617F were more sensitive to the inhibition of lestaurtinib than cells wi...
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Many drug or single nucleotide polymorphism (SNP)-related resources and tools have been developed, but connecting and integrating them is still a challenge. Here, we describe a user-friendly web-based software package, named Drug-SNPing, which provides a platform for the integration of drug information (DrugBank and PharmGKB), protein-protein interactions (STRING), tagSNP selection (HapMap) and...
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The main aim of this paper is to illustrate the potentials that the use of robotic and mechatronic technologies (in combination with advanced biomechanical models) can offer to help elderly people identifying and slowing down the effects of the age-related modifications of the neuro-muscoloskeletal systems and therefore increasing their possibility of staying at home reducing the hospetalizatio...
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ژورنال
عنوان ژورنال: Aging
سال: 2009
ISSN: 1945-4589
DOI: 10.18632/aging.100048